Physiological Processes And Treatment Of Plaque Psoriasis

Physiological Processes Treatment of Plaque Psoriasis Psoriasis is a chronic immune-mediated inflammatory skin disease that is not contagious but has no cure. Psoriasis often presents as patches of thick red skin and silvery scales called plaque psoriasis. This proliferation of skin cells often affect the face, trunk, and extremities and have a familial tendency. Sudden onset is often triggered by stress, trauma, medications, or infection and is an equal opportunistic disease that manifests on the skin and can begin in childhood or at any age (Arcangelo, 2013). Approximately five million adults suffer from this inflammatory disease and psoriasis can occur in all age groups (National Institute of Arthritis and Musculoskeletal and Skin Diseases [NIH], 2013). The purpose of this paper is to explore the pathophysiological, maladaptive, and psychosocial effects of psoriasis; discuss and explore the pharmacological interventions for pediatric and geriatric patients, and synthesize the body’s response to treatments available. Pathophysiology of Psoriasis Psoriasis is an autoimmune disorder that develops when there is a maladaptation in the body’s defense system. This disease is driven by the immune system involving the Th lymphocyte cells. Under normal homeostasis, the regeneration of epidermis tissue renew under normal pathological conditions with the shedding of the outer layer of skin every 14-20 days. During flair-ups, lymphocytes infiltrate into the epidermalShow MoreRelatedThe Effects Of Psoriasis On The Development And Exacerbation Of Psoriasis997 Words   |  4 Pagesin Psoriasis, Psoriasis is a chronic, inflammatory skin disease with an approximate 2-3% prevalence in the general population. The etiology of psoriasis is not fully understood, but it appears to be multifactorial, involving both genetic and environmental influences. Among these factors, emotional stress is considered to play an important role in the onset and exacerbation of psoriasis. Emotional stress may influence the development and exacerbation of psoriasis. The proportion of psoriasis patientsRead MoreSymptoms And Treatment Of Psoriasis1474 Words   |  6 Pagesindividual at a rate higher than expected by chance (Bonavita and De Simone, 2008). Although psoriasis has been previously thought to be a disease solely affecting primarily the skin and the joints, our understanding of the comorbidities that may be associated with this disease has grown significantly. Recent evidence has even suggested an increased over all risk of mortality in patients with severe psoriasis (Gelfand JM et al., 2007). The presence of comorbidities in dermatology is of interest forRead MoreCase Study on Hypokalemia8797 Words   |  36 Pagesmorning stiffness. Skin manifestations are often experienced by patients with SLE such as subacute cutaneous lupus erythematosus (papulosquamous or annular polycyclic lesions), discoid lupus erythematosus (chronic rash with erythematous papules and or plaques that may cause changes in pigmentation and scarring. The most common skin manifestation is acute cutaneous lesion (butterfly rash) a butterfly shaped rash across the bridge of the nose and cheeks. Pericarditis is a common cardiovascular manifestation